True or False: The entire dose of Narcan must be administered in one nostril.

The statement that the entire dose of Narcan must be administered in one nostril is true. When administering Narcan (naloxone), the recommended method for use in adults involves delivering the entire dose in one nostril. This is done to ensure maximum absorption and effectiveness, as Narcan is designed to act quickly to reverse the effects of opioid overdose.

Administering the full dose in one nostril allows for higher concentrations to be delivered directly to the nasal mucosa, where it can enter the bloodstream more efficiently. If the entire dose were split between both nostrils, it could dilute the impact and potentially reduce the drug's effectiveness in reversing opioid overdose. Therefore, it is critical to adhere to the established protocol of administering the full dose in a single nostril to achieve the desired outcome.

The other choices reflect misinterpretations of Narcan administration, such as suggesting that the dose could be split or that the patient's alertness might dictate how the medication is given, which can compromise the effectiveness of the treatment in emergency scenarios.